Pairings shown with regional seed. All games on Friday, November 21, at 7 p.m.

Division I

Region 1

No. 1 Lakewood St. Edward (10-2) vs. No. 2 Mentor (12-0) at Parma Byers Field at Robert Boulton Stadium

Region 2

No. 1 Middletown (10-2) vs. No. 6 Huber Heights Wayne (9-4) at Trotwood-Madison High School Attorney Michael L. Wright SportsPlex

Region 3

No. 1 Lewis Center Olentangy Orange (12-0) vs. No. 2 Pickerington Central (11-1) at Columbus Historic Crew Stadium

Region 4

No. 1 Cincinnati Elder (12-0) vs. No. 3 Cincinnati St. Xavier (9-2) at Mason High School Tri-Health/Beacon Stadium

Division II

Region 5

No. 1 Akron Archbishop Hoban (10-1) vs. No. 2 Cuyahoga Falls Walsh Jesuit (10-1) at Bedford High School Bearcat Stadium

Region 6

No. 1 Medina Highland (12-0) vs. No. 3 Avon (11-1) at Brunswick High School Brunswick Auto Mart Stadium

Region 7

No. 1 Sunbury Big Walnut (11-1) vs. No. 3 Massillon Washington (9-3) at Zanesville High School Sulsberger Stadium

Region 8

No. 1 Cincinnati Anderson (12-0) vs. No. 3 Trotwood-Madison (8-3) at West Chester Lakota West High School Firebird Stadium

Division III

Region 9

No. 2 Cuyahoga Falls CVCA (11-0) vs. No. 4 Cleveland Villa Angela-St. Joseph (10-1) at Twinsburg High School Tiger Stadium

Region 10

No. 5 Rocky River (11-2) vs. No. 6 Toledo Central Catholic (9-4) at Clyde High School Robert J. Bishop Jr. Stadium

Region 11

No. 1 Columbus Bishop Watterson (11-0) vs. No. 3 Steubenville (9-2) at Newark High School White Field

Region 12

No. 1 London (12-0) vs. No. 2 Tipp City Tippecanoe (12-0) at Fairborn High School Skyhawk Stadium

Division IV

Region 13

No. 1 Perry (10-2) vs. No. 2 Cleveland Glenville (9-3) at Ravenna High School Portage Community Bank Stadium/Harry Gilchrist Field

Region 14

No. 1 Shelby (12-0) vs. No. 2 Galion (11-1) at Mansfield Arlin Field

Region 15

No. 1 New Lexington (11-1) vs. No. 2 Gnadenhutten Indian Valley (11-0) at Coshocton High School Stewart Field

Region 16

No. 1 Cincinnati Indian Hill (12-0) vs. No. 2 Germantown Valley View (11-1) at Fairfield High School Alumni Stadium

Division V

Region 17

No. 1 Youngstown Cardinal Mooney (9-2) vs. No. 2 Girard (12-0) at Canfield South Range High School Rominger Athletic Complex

Region 18

No. 1 Liberty Center (12-0) vs. No. 3 Genoa Area (11-1) at Fostoria High School Memorial Stadium

Region 19

No. 1 Wheelersburg (12-0) vs. No. 3 Nelsonville-York (12-0) at Hamilton Township High School Alumni Stadium

Region 20

No. 2 Lewistown Indian Lake (10-2) vs. No. 8 Richwood North Union (9-4) at Marysville High School IMPACT Stadium

Division VI

Region 21

No. 1 Kirtland (12-0) vs. No. 7 Sugarcreek Garaway (10-2) at Louisville High School Leopard Stadium

Region 22

No. 2 Bascom Hopewell-Loudon (11-1) vs. No. 9 Carey (9-4) at Findlay Donnell Stadium

Region 23

No. 3 West Jefferson (11-1) vs. No. 5 North Robinson Colonel Crawford (12-1) at Marengo Highland High School Covrett Stadium Fishburn Family Field

Region 24

No. 5 Coldwater (9-4) vs. No. 6 Anna (10-3) at Piqua High School Alexander Stadium

Division VII

Region 25

No. 1 McDonald (12-0) vs. No. 3 Mogadore (11-1) at Macedonia Nordonia High School Boliantz Stadium

Region 26

No. 3 Leipsic (11-1) vs. No. 4 Columbus Grove (9-3) at Lima Shawnee High School Shawnee Stadium

Region 27

No. 1 Jeromesville Hillsdale (11-1) vs. No. 11 Danville (8-5) at West Lafayette Ridgewood High School Generals Stadium

Region 28

No. 1 Maria Stein Marion Local (12-0) vs. No. 2 St. Henry (11-1) at Wapakoneta High School Mercy Health VFW Post 8445 Field